Reversing muscle degeneration

756 Muscle Degeneration

Muscle degeneration and a shock syndrome, which frequently results in death, follow the release of limb tourniquets. Albumin and other plasma components are transferred into the affected muscle tissue (1-4) while toxic products of autolysis and hemolytic substances appear in the circulating blood (5-7). I t is possible that this abnormal transfer results in part from damage of capillaries and m...

Skeletal Muscle – Degeneration

Invertebrate models of age-related muscle degeneration.

Functional and structural deterioration of muscles is an inevitable consequence of ageing in a wide variety of animal species. What underlies these changes is a complex network of interactions between the muscle-intrinsic and muscle-extrinsic factors, making it very difficult to distinguish between the cause and the consequence. Many of the genes, structures, and processes implicated in mammali...

Muscle weakness causes joint degeneration in rabbits.

OBJECTIVE The objective of this study was to investigate the effects of botulinum toxin type-A (BTX-A) induced quadriceps weakness on micro-structural changes in knee cartilage of New Zealand White (NZW) rabbits. DESIGN Fifteen rabbits were divided randomly into an experimental and a sham control group. Each group received a unilateral single quadriceps muscle injection either with saline (sh...

Ethanol Exposure Causes Muscle Degeneration in Zebrafish

Alcoholic myopathies are characterized by neuromusculoskeletal symptoms such as compromised movement and weakness. Although these symptoms have been attributed to neurological damage, EtOH may also target skeletal muscle. EtOH exposure during zebrafish primary muscle development or adulthood results in smaller muscle fibers. However, the effects of EtOH exposure on skeletal muscle during the gr...